MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling
Lynn Elton, Isabelle Carpentier, Jens Staal, Yasmine Driege, Mira Haegman, Rudi Beyaert
FEBS J . 2016 Feb;283(3):403-12. doi: 10.1111/febs.13597. Epub 2015 Nov 26.
Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold
David W Vredevoogd, Thomas Kuilman, Maarten A Ligtenberg, Julia Boshuizen, Kelly E Stecker, Beaunelle de Bruijn, Oscar Krijgsman, Xinyao Huang, Juliana C N Kenski, Ruben Lacroix, Riccardo Mezzadra, Raquel Gomez-Eerland, Mete Yildiz, Ilknur Dagidir, Georgi Apriamashvili, Nordin Zandhuis, Vincent van der Noort, Nils L Visser, Christian U Blank, Maarten Altelaar, Ton N Schumacher, Daniel S Peeper
Cell 2019 Jul 25;178(3):585-599.e15. doi: 10.1016/j.cell.2019.06.014. Epub 2019 Jul 11.
RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells
Zhengkui Zhang , Xiangjun Kong , Maarten A Ligtenberg , Susan E van Hal-van Veen , Nils L Visser , Beaunelle de Bruijn, Kelly Stecker, Pim W van der Helm, Thomas Kuilman , Esmée P Hoefsmit, David W Vredevoogd, Georgi Apriamashvili, Beau Baars, Emile E Voest, Sjoerd Klarenbeek, Maarten Altelaar, Daniel S Peeper
Cell Rep Med 2022 Jun 21;3(6):100655. doi: 10.1016/j.xcrm.2022.100655.
The (re)discovery of tumor-intrinsic determinants of immune sensitivity by functional genetic screens
D W Vredevoogd, G Apriamashvili, D S Peeper
Immunooncol Technol. 2021 Oct 28:11:100043. doi: 10.1016/j.iotech.2021.100043. eCollection 2021 Oct.
Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling
Georgi Apriamashvili, David W Vredevoogd, Oscar Krijgsman, Onno B Bleijerveld, Maarten A Ligtenberg, Beaunelle de Bruijn, Julia Boshuizen, Joleen J H Traets, Daniela D'Empaire Altimari, Alex van Vliet, Chun-Pu Lin, Nils L Visser, James D Londino, Rebekah Sanchez-Hodge, Leah E Oswalt, Selin Altinok, Jonathan C Schisler, Maarten Altelaar, Daniel S Peeper
Nat Commu. 2022 Apr 8;13(1):1923. doi: 10.1038/s41467-022-29442-x.
Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
Chun-Pu Lin, Pierre L Levy, Astrid Alflen, Georgi Apriamashvili, Maarten A Ligtenberg, David W Vredevoogd, Onno B Bleijerveld, Ferhat Alkan, Yuval Malka, Liesbeth Hoekman, Ettai Markovits, Austin George, Joleen J H Traets, Oscar Krijgsman, Alex van Vliet, Joanna Poźniak, Carlos Ariel Pulido-Vicuña, Beaunelle de Bruijn, Susan E van Hal-van Veen, Julia Boshuizen, Pim W van der Helm, Judit Díaz-Gómez, Hamdy Warda, Leonie M Behrens, Paula Mardesic, Bilal Dehni, Nils L Visser, Jean-Christophe Marine, Gal Markel, William J Faller, Maarten Altelaar, Reuven Agami, Michal J Besser, Daniel S Peeper
Cancer Cell. 2024 Mar 13:S1535-6108(24)00060-6. doi: 10.1016/j.ccell.2024.02.016. Online ahead of print.
Collaborators
We are a team with broad and deep expertise in cancer biology, functional genomics and small molecule oncology drug discovery. We are focused on the development of novel precision oncology therapies, enabled by the Immunogram drug discovery engine.
